The EIC action "Electrochemically-enabled high-throughput peptidomics for next-generation precision medicine (ElectroMed) is a FET-Open project running from January 2020 until June 2023. ELECTROMED brings together scientists from different partners in Europe, neighbouring countries and international partner countries.
The coordinator of the action is Dr. César Pascual García. The executive committee is completed by Dr. Thomas Østerbye as Scientific & Technical manager and Dr. Damien Lenoble as exploitation manager.
The Steering committee is composed by the executive committee and the representants of the other institutions Dr. Vihar Georgiev, Prof. David Andreu, Dr. Wouter Olthuis and Dr. Julia Sepúlveda.
In the last decade, precision (or personalized) medicines have become relevant research approaches in the cure of high prevalence diseases, such as cancers and infections. Despite the growing number of technologies, as for example protein screening instruments, the development of individual-based treatments remains a very expensive and time consuming process. Recent scientiﬁc advances proved the potential of immunological treatments in the remissions of certain cancer types. In silico methods based on computer algorithms allow to identify peptides candidates enabling an eﬃcient immune system response in the ﬁght against cancers. However, those promising methods, based on prediction models, show a high rate of false positive results. In addition, the interactions between these molecules and the immune system cannot be fully characterized due to the enormous number of combinations, as well as the current instruments constraints to both spot and synthetize arrays of complex molecular entities while managing small quantities of reagents.
The objective of ElectroMed is to build and validate a proof-of-concept prototype of a programmable high-throughput peptide microarray technology. This European funded project aims to integrate electrochemical synthesis of peptide bioreceptors with sensitive Field Eﬀect Transistors (FETs) in order to enable programmable in situ protein detection. We will make use of a system utilizing nano-liter chemistry on a chip for the functionalization of FinFETs – ﬁn ﬁeld-eﬀect transistor, which is a multigate device built on a substrate - sensors for high-performance data acquisition within a microﬂuidic-driven multiplexed platform for parallel screening. During this multidisciplinary project we will develop the concept of multiplexed electrochemical peptide synthesis (EPS), and improve the capabilities of FinFET sensors, in order to embed them into a unique cost-eﬀective lab-on-chip prototype. The latter will be then validated by the researchers in laboratory-relevant conditions for the screening of peptide sequences in cancer vaccines.
ElectroMed will provide a revolutionary technology for next generation precision medicine by developing the ﬁrst fully-programmable in situ protein screening instrument. By designing a microﬂuidic-driven multiplexed platform, ElectroMed will enable a faster, aﬀordable, and more eﬃcient technology than current protein screening instruments. Consequently, this unprecedent device will signiﬁcantly ease and reduce the price of protein screening. This proof-of-concept prototype will not only open the path to new personalized medicine applications, but it might also be of great interest for the food sector (e.g. food authenticity and traceability, GMOs or toxin detection), as well as for the environmental remediation or defense (e.g. detection of biological warfare agents).
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This project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 862539-Electromed-FET OPEN.